Publication Date 01/06/2013         Volume. 5 No. 5   
Information to Pharmacists

Editorial

From the desk of the editor

Welcome to the June homepage edition for i2P (Information to Pharmacists) E-Magazine.
The editor’s desk has been vacant for nearly a month to enable a short vacation to happen, and gratefully it has stirred some sort of a revival.
The volume of work unpublished over May will be reorganised and will appear gradually over future editions.
Since resuming “the desk” the pressure has recommenced, but that is part of the job.
This month we have featured Gerald Quigley as he illustrates an evidence-based complementary medicine that helps Alzheimer patients. The product is already helping patients but is being criticised because of a perceived lack of “quality” in its evidence profile.
Mark Coleman has jumped in to point out the lack of quality in mainstream evidence for drugs, and I find it quite appalling that a serial complainer can justify any mainstream evidence as being “gold standard”.
Read Mark’s article under the title of “Research and other Medical Wonders”.

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Drug allergy breakthrough

Staff Researcher

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Editing and Researching news and stories about Australian and International Pharmacy Issues

Australian researchers have discovered why people develop life-threatening allergies after receiving treatment for conditions such as epilepsy and AIDS.
The research, by the University of Melbourne and Monash University, could lead to the development of a diagnostic test to determine drug hypersensitivity.

Professor Jamie RossjohnProfessor Jamie Rossjohn

Published today in Nature, the study revealed how some drugs inadvertently target the body's immune system to alter how it perceives it’s own tissues, making them appear foreign.

The immune system then attacks the foreign nature of the tissues as if they were incompatible transplants.

Professor Jamie Rossjohn from Monash University, who led the study with Professor James McCluskey of the University of Melbourne, and Professor Tony Purcell from the University of Melbourne’s Bio21 Institute, said the study showed the biological mechanisms by which a person's exact tissue type determined whether they would develop the drug allergy.

"Our findings represent the culmination of a seven-year odyssey for the collaborative groups involved in this study," Professor Rossjohn said.

"We have provided insight into a general mechanism of drug hypersensitivity and the HLA locus."

Professor McCluskey said an entire class of drug allergy was likely to be explained by the discovery.

“There are several drugs that can cause life-threatening skin rashes and other symptoms such as fever, diarrhea, muscle aches and pains," Professor McCluskey said.

“A simple blood test may help to predict adverse reactions in the treatment of a broad range of conditions like AIDS, epilepsy, gout and infections.”

The study was done in collaboration with the Queensland Institute for Medical Research and was supported by the Australian Research Council and the National Health and Medical Research Council of Australia.

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